Collect. Czech. Chem. Commun. 1994, 59, 461-466

The Gas-Solid-Phase 2,5-Dioxopiperazine Synthesis. Cyclization of Vaporous Dipeptides on Silica Surface

Vladimir A. Basiuk and Taras Yu. Gromovoy

Institute of Surface Chemistry, Academy of Sciences of the Ukraine, Prospekt Nauki 31, Kiev 252650, Ukraine


The "gas solid-phase" method is used for the preparation of both symmetric and asymmetric 2,5-dioxopiperazines via cyclization of vaporous linear dipeptides in the presence of silica.