Collect. Czech. Chem. Commun. 1993, 58, 1169-1179


Alfonz Rybára, Peter Turčánib and Juraj Alföldia

a Institute of Chemistry, Slovak Academy of Sciences, 842 38 Bratislava, Slovak Republic
b Department of Neurology, School of Medicine, Comenius University, 813 64 Bratislava, Slovak Republic


1-(2-Oxopropyl)-, 1-(3-oxobutyl)-, and 1-(5-oxohexyl)-3,7,8-trialkyl-3,7-dihydro-1H-purine-2,6-diones (Ia -Xa, Ib - Xb, and Ic - Xc, respectively) were prepared by alkylation of alkali metal salts of 3,7,8-trialkyl-3,7-dihydro-1H-purine-2,6-diones XI - XX to methyl vinyl ketone. The effect of the final compounds I - X on aggregation of thrombocytes and erythrocytes was investigated.