Collect. Czech. Chem. Commun. 1993, 58, 1164-1168

Regio- and Stereoselective Tritiation of the Juvenoid Analog W 328

Tomáš Elberta, Bohuslav Černýa, Zdeněk Wimmerb and Leila Sergentc

a Institute of Nuclear Biology and Radiochemistry, Academy of Sciences of the Czech Republic, 142 20 Prague 4, Czech Republic
b Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 166 10 Prague 6, Czech Republic
c Services des Molécules Marquées, CEN-Saclay, 91191 Gif-sur-Yvette Cedex, France


The juvenoid analog 2-(4-(2-(ethoxycarbamato)ethoxy)benzyl)-1-cyclohexanone ethylene acetal (I) (W 328) was labelled by 3H in the benzyl position by the CESG method. 3H NMR revealed the stereoselectivity of the labelling. The results are compared with the data published in the literature and discussed in the terms of stereoelectronic requirements.