Collect. Czech. Chem. Commun. 1993, 58, 575-587

New Synthesis of N-Acylurea Derivatives

Peter Kutschy, Milan Dzurilla, Vlastimír Ficeri and Dušan Koščík

Department of Organic Chemistry, Faculty of Natural Science, Šafárik University, 041 67 Košice, Slovak Republic


S-Allyl N-acylmonothiocarbamates react in boiling benzene with primary and secondary amines in the presence of catalytic amounts of triethylamine. In this reaction, the S-allyl group is replaced with the amino group under formation of N-acylurea derivatives in 45 - 90% yields. The wide applicability of the reaction is demonstrated by the synthesis of eighty four N-acyl-N'-substituted and N-acyl-N',N'-disubstituted ureas with various aliphatic, aromatic and heterocyclo substituents.