Collect. Czech. Chem. Commun. 1992, 57, 1960-1966
https://doi.org/10.1135/cccc19921960

Acylation of the N-Terminus of B2 Bradykinin Antagonists with Bulky Substituents Dramatically Increases Potency

Bernard Lammeka, Yasushi Itob, Irene Gavrasb and Haralambos Gavrasb

a Department of Chemistry, University of Gdańsk, Sobieskiego 18, 80-952 Gdansk, Poland
b Hypertension Section and Department of Medicine, Thorndike Memorial Laboratory, Boston City Hospital and the Department of Medicine, University Hospital, Boston University School of Medicine, U.S.A.

Individual author index pages


Other CCCC articles of these authors

  • Adam Prahl, Tomasz Wierzba, Pawel Winklewski, Magdalena Wszedybyl, Maciej Cherek, Witold Juzwa and Bernard Lammek
    Influence of C-Terminal Modifications of Bradykinin Antagonists on Their Activity
    1997, Vol. 62, Issue 12, pp. 1940–1946 [Abstract]
  • Jiřina Slaninová, Malgorzata Czaja and Bernard Lammek
    Synthesis and Biological Activity of Four Vasopressin Analogs Modified in Position 3 with β-Thienylalanine
    1995, Vol. 60, Issue 4, pp. 681–686 [Abstract]
  • Ewa Konieczna, Malgorzata Czaja, Bernard Lammek, Jiřina Slaninová and Tomislav Barth
    Synthesis and Some Pharmacological Properties of Six New Analogs of Arginine-Vasopressin Substituted in Position 2 with β-Thienylalanine or Prolonged on the N-Terminus with 1-Adamantaneacetic Acid
    1993, Vol. 58, Issue 12, pp. 2994–2999 [Abstract]
  • Malgorzata Czaja, Ewa Konieczna, Bernard Lammek, Jiřina Slaninová and Tomislav Barth
    Analogs of Arginine-Vasopressin Substituted in Position 2 with L-4-Cl-Phenylalanine or D-Phenylglycine
    1993, Vol. 58, Issue 3, pp. 675–680 [Abstract]
  • Bernard Lammek, Yi-Xin Wang and Haralambos Gavras
    Synthesis and some pharmacological properties of three new bradykinin antagonists
    1991, Vol. 56, Issue 7, pp. 1539–1544 [Abstract]
  • Bernard Lammek, Izabela Derdowska, Gotfryd Kupryszewski, Jiřina Slaninová and Tomislav Barth
    Synthesis and biological activity of four vasopressin analogues substituted in position 2 by p-fluorophenylalanine
    1991, Vol. 56, Issue 4, pp. 933–938 [Abstract]
  • Bernard Lammek, Izabela Derdowska, Tomasz M. Wierzba and Witold Juzwa
    Synthesis of four new V1 antagonists of arginine-vasopressin (AVP) containing new thioacids at position 1 and their vasoconstrictor activity towards isolated mesenteric arterial vessels of rats
    1991, Vol. 56, Issue 2, pp. 491–498 [Abstract]
  • Bernard Lammek, Izabela Derdowska, Gotfryd Kupryszewski, Jiřina Slaninová, Tomislav Barth and Pavel Hrbas
    Synthesis, biological activity and receptor binding affinity of six new antagonists of [8-L-arginine]vasopressin
    1989, Vol. 54, Issue 12, pp. 3374–3380 [Abstract]
  • Bernard Lammek, Zbigniew Maćkiewicz, Izabela Derdowska, Hanna Świderska, Adam Nowosławski and Gotfryd Kupryszewski
    Synthesis of hepatitis B surface antigen pre-S2 region fragments and studies on their immunogenicity
    1988, Vol. 53, Issue 11, pp. 2952–2956 [Abstract]
  • Krzysztof Bankowski, Bernard Lammek, Marian Kruszynski, Maurice Manning, Janny Seto and Wilbur H. Sawyer
    2-O-methyl and 2-O-ethyl-tyrosine derivatives of [8-arginine]vasopressin analogs: Highly specific antidiuretic agonists
    1988, Vol. 53, Issue 11, pp. 2617–2626 [Abstract]