Collect. Czech. Chem. Commun. 1992, 57, 1758-1769

Novel Synthesis of 4-Bromo-3-oxo-2-phenylhydrazonobutyronitrile and 4-Cyano-3-oxo-2-phenylhydrazonobutyronitrile: Synthesis of Pyridazine, Thiazole, 1,2,4-Triazine and Pyrido[2,3-e]-1,2,4-triazine Derivatives

Rafat Milad Mohareba and Nadia Iskander Abdel-Sayedb

a Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt
b Chemistry Department, College for Girls, Ain Shams University, Heliopolis, Cairo, Egypt


4-Bromo-3-oxo-2-phenylhydrazono-butyronitrile (II) reacted with thioamides to afford the thiazole derivatives III and VI. Compound II reacted with nucleophilic reagents to afford XIIIa and XIIIb. The reactivity of XIIIa with some chemical reagents was studied to afford pyridazine, thiazole, 1,2,4-triazine derivatives.