Collect. Czech. Chem. Commun.
1992, 57, 1758-1769
https://doi.org/10.1135/cccc19921758
Novel Synthesis of 4-Bromo-3-oxo-2-phenylhydrazonobutyronitrile and 4-Cyano-3-oxo-2-phenylhydrazonobutyronitrile: Synthesis of Pyridazine, Thiazole, 1,2,4-Triazine and Pyrido[2,3-e]-1,2,4-triazine Derivatives
Rafat Milad Mohareba and Nadia Iskander Abdel-Sayedb
a Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt
b Chemistry Department, College for Girls, Ain Shams University, Heliopolis, Cairo, Egypt
Abstract
4-Bromo-3-oxo-2-phenylhydrazono-butyronitrile (II) reacted with thioamides to afford the thiazole derivatives III and VI. Compound II reacted with nucleophilic reagents to afford XIIIa and XIIIb. The reactivity of XIIIa with some chemical reagents was studied to afford pyridazine, thiazole, 1,2,4-triazine derivatives.
