Collect. Czech. Chem. Commun. 1991, 56, 2986-2990

6-(ω-Guanidinoalkyl)- and 6-(ω-imidazolinaminoalkyl)-5,6,7,8-tetrahydrodibenz[c,e]azocines

Fridrich Szemesa, Alfonz Rybárb and Eva Solčániovác

a Drug Research Institute, 900 01 Modra
b Institute of Chemistry, Slovak Academy of Sciences, 842 38 Bratislava
c Department of Organic Chemistry, Comenius University, 842 15 Bratislava


Guanidine derivatives of 5,6,7,8-tetrahydrodibenz[c,e]azocine IV and V were prepared by a three-step synthesis starting from 5,6,7,8-tetrahydrodibenz[c,e]azocine (I) via the corresponding 6-(ω-cyanoalkyl) II and 6-(ω-aminoalkyl) derivatives III; finaly, compounds III were treated with either methylisothiuronium halide or methylthioimidazolinium halide.