Collect. Czech. Chem. Commun. 1990, 55, 2317-2320

Peptide synthesis under high pressure by aminolysis of methyl and phenyl esters

Vladimír Guta, Zinaida G. Makarovab, Alexander S. Molokoedovc and Victor M. Zhulinb

a Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague 6, Czechoslovakia
b Zelinsky Institute of Organic Chemistry, U.S.S.R. Academy of Sciences, 117913 Moscow, U.S.S.R.
c Institute of Experimental Cardiology, U.S.S.R. Academy of Medical Sciences, 121552 Moscow, U.S.S.R.


High pressure may, depending on solvent, enhance the reactivity of methyl and phenyl ester of the N-protected dipeptide Ala-Ala with the amino component, valine tert-butyl ester, yielding the protected tripeptide. Results of this reaction in several solvents are discussed.