Collect. Czech. Chem. Commun. 1990, 55, 485-490

Direct esterification of 2-methoxy-2-phenyl-3,3,3-trifluoropropionic acid: A reinvestigation

Aleš Svatoš, Irena Valterová, David Šaman and Jan Vrkoč

Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague 6


The direct esterification of enantiomeric 2-methoxy-2-phenyl-3,3,3-trifluoropropionic acids (MTPA) was reinvestigated. Preferential formation of one of the diastereoisomeric esters was avoided by using three equivalents of MTPA. Chromatographic behaviour of the obtained MTPA esters is discussed.