Crossref Cited-by Linking logo

Collect. Czech. Chem. Commun. 1989, 54, 1082-1091
https://doi.org/10.1135/cccc19891082

Studies on condensed pyrazoles: Synthesis of new methyl and amino pyrazolo[1,5-a]pyrimidines and of pyrazolo[5,1-c][1,2,4]triazines

Mohamed Hilmy Elnagdia, Nadia Hassen Tahab, Fatma Abdel Maksoud Abd El Alla, Ramadan Maawad Abdel-Motalebc and Fivian Farouk Mahmoudb

a Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt
b Department of Chemistry, Faculty of Science, El-Azhar University, Cairo, Egypt
c Department of Chemistry and Physics, Faculty of Education at Fayoum, Cairo University, Fayoum Egypt

Crossref Cited-by Linking

  • Elbadawy Hemmat A., Abd‐El‐Nabey Bashir A., Ali Ali El‐Dissouky, Elsayed Eman Hassan: The development of an unexpected Cu(I)‐pyrazolo pyrimidine‐based complex: Synthesis, spectroscopic characterizations, and biological activity. Applied Organom Chemis 2022, 36. <https://doi.org/10.1002/aoc.6843>
  • Moustafa Moustafa Sherif, Nour-Eldeen Ahmed Moukhtar, Al-Mousawi Saleh Mohamed, El-Hameed Afaf Abd, Magdy Michael, Sadek Kamal Usef: Regioselectivity in the reaction of 5-amino-3-anilino-1H-pyrazole-4-carbonitrile with cinnamonitriles and enaminones: Synthesis of functionally substituted pyrazolo[1,5-a]pyrimidine derivatives. Green Processing and Synthesis 2022, 11, 116. <https://doi.org/10.1515/gps-2022-0009>
  • Secrieru Alina, O’Neill Paul Michael, Cristiano Maria Lurdes Santos: Revisiting the Structure and Chemistry of 3(5)-Substituted Pyrazoles. Molecules 2019, 25, 42. <https://doi.org/10.3390/molecules25010042>
  • El‐Mekabaty Ahmed, Mesbah Ahmed, Fadda Ahmed A.: An Efficient and Facile Synthesis of Functionalized Indole‐3‐yl Pyrazole Derivatives Starting from 3‐Cyanoacetylindole. Journal of Heterocyclic Chem 2017, 54, 916. <https://doi.org/10.1002/jhet.2654>
  • Fadda Ahmed A., Rabie Ramy, Bondock Samir, Etman Hassan A.: Derivational, Structural, and Biological Studies of Some New Pyrazolyl, Isoxazolyl, Pyrimidinyl, Pyridazinyl, and Pyridopyridazinyl from 4‐Substituted Antipyrine. Journal of Heterocyclic Chem 2017, 54, 1304. <https://doi.org/10.1002/jhet.2707>
  • Mohareb Rafat M., Abbas Nermeen S., Mohamed Abeer A.: Synthesis of tetrahydropyrazolo-quinazoline and tetrahydropyrazolo-pyrimidocarbazole derivatives as potential anti-prostate cancer agents and Pim-1 kinase inhibitors. Med Chem Res 2017, 26, 1073. <https://doi.org/10.1007/s00044-017-1811-3>
  • Mohareb Rafat M., Abdo Nadia Y. Megally, Wardakhan Wagnat W.: Synthesis and evaluation of pyrazolo[5,1-b]quinazoline-2-carboxylate, and its thiazole derivatives as potential antiproliferative agents and Pim-1 kinase inhibitors. Med Chem Res 2017, 26, 2520. <https://doi.org/10.1007/s00044-017-1951-5>
  • Darweesh Ahmed F., Mekky Ahmed E. M., Salman Amani A., Farag Ahmad M.: Efficient, microwave-mediated synthesis of benzothiazole- and benzimidazole-based heterocycles. Res Chem Intermed 2016, 42, 4341. <https://doi.org/10.1007/s11164-015-2279-8>
  • Bondock Samir, Tarhoni Abd El-Gaber, Fadda Ahmed A.: Regioselective Synthesis of Some New Pyrazolo[1,5-a ]pyrimidines, Pyrazolo[1,5-a ]quinazoline and Pyrimido[4′,5′:3,4]pyrazolo[1,5-a ] pyrimidines Containing Thiazole Moiety. J. Heterocyclic Chem. 2015, 52, 1792. <https://doi.org/10.1002/jhet.2278>
  • Ledenyova I. V., Didenko V. V., Shikhaliev Kh. S.: Chemistry of Pyrazole-3(5)-Diazonium Salts (Review)*. Chem Heterocycl Comp 2014, 50, 1214. <https://doi.org/10.1007/s10593-014-1585-1>
  • Gamal-Eldeen Amira M., Hamdy Nehal A., Abdel-Aziz Hatem A., El-Hussieny Enas A., Fakhr Issa M.I.: Induction of intrinsic apoptosis pathway in colon cancer HCT-116 cells by novel 2-substituted-5,6,7,8-tetrahydronaphthalene derivatives. European Journal of Medicinal Chemistry 2014, 77, 323. <https://doi.org/10.1016/j.ejmech.2014.03.021>
  • Ledenyova Irina V., Didenko Vitaly V., Dotsenko Victor V., Shikhaliev Khidmet S.: Azo-coupling of pyrazole-3(5)-diazonium chlorides with cyanothioacetamide: a convenient synthesis of pyrazolo[5,1-c][1,2,4]triazine-3-carbothioamides. Tetrahedron Letters 2014, 55, 1239. <https://doi.org/10.1016/j.tetlet.2014.01.010>
  • M. Farag Ahmad, A. Elsayed Mohamed, A. Ali Korany: Synthesis of Some New Pyridine-2,6-bis-heterocycles. HETEROCYCLES 2012, 85, 1913. <https://doi.org/10.3987/COM-12-12483>
  • Gouda M.A., Berghot M.A., Shoeib A.I., Khalil A.M.: Synthesis and antimicrobial of new anthraquinone derivatives incorporating pyrazole moiety. Eur J Med Chem 2010, 45, 1843. <https://doi.org/10.1016/j.ejmech.2010.01.021>
  • Al-Omran Fatima, El-Khair Adel A.: Studies with 2-(acetonylthio)benzothiazole. New routes to isoxazoles, isoxazolo[3,4-b]pyridines, pyrazolo[1,5-a]pyrimidines, pyridines and quinolizines. Journal of Chemical Research 2009, 2009, 433. <https://doi.org/10.3184/030823409X464412>
  • A. Kheder Nabila: Convenient Synthesis of Novel Bis(hydrazone) and Bis(indole) Derivatives. HETEROCYCLES 2009, 78, 1281. <https://doi.org/10.3987/COM-08-11615>
  • Bondock Samir, Rabie Ramy, Etman Hassan A., Fadda Ahmed A.: Synthesis and antimicrobial activity of some new heterocycles incorporating antipyrine moiety. Eur J Med Chem 2008, 43, 2122. <https://doi.org/10.1016/j.ejmech.2007.12.009>
  • Shawali Ahmad Sami, Mosselhi Mosselhi A., Altablawy Farag M.A., Farghaly Thoraya A., Tawfik Nagla M.: Synthesis and tautomeric structure of 3,7-bis(arylazo)-6-methyl-2-phenyl-1H-imidazo[1,2-b]pyrazoles in ground and excited states. Tetrahedron 2008, 64, 5524. <https://doi.org/10.1016/j.tet.2008.03.096>
  • Shawali Ahmad S., Mosselhi Mosselhi A. N., Farghaly Thoraya A., Shehata Mohamed R., Tawfik Nagla M.: Synthesis and Tautomeric Structure of 3,6-bis(arylazo)pyrazolo [1,5-a]pyrimidine-5,7(4H,6H)-diones. Journal of Chemical Research 2008, 2008, 452. <https://doi.org/10.3184/030823408X339782>
  • Ghozlan Said Ahmed Soliman, Abdelhamid Ismail Abdelshafy, Gaber Hatem, Elnagdi Mohamed Hilmy: Studies with Functionally Substituted Enamines: Synthesis of New Aminoazolo-Pyrimidines and -1,2,4-Triazines. Journal of Chemical Research 2004, 2004, 789. <https://doi.org/10.3184/0308234043431230>
  • Raslan M. A., El‐Aal R. M. Abd, Hassan M. E., Ahamed N. A., Sadek K. U.: Studies on Fused Azoles: Synthesis of Several Polyfunctionally Substituted Fused Azoles. J Chinese Chemical Soc 2001, 48, 91. <https://doi.org/10.1002/jccs.200100017>
  • Al-Afaleq Eljazi I.: Heterocyclic Synthesis via Enaminonitriles: an Efficient, One Step Synthesis of Some Novel Azolo[1,5-α]Pyrimidine, Pyrimido[1,2-α]-Benzimidazole, Pyrido[1,2-α]Benzimidazole Pyrimidine and Pyrazole Derivatives. Synthetic Communications 2000, 30, 1985. <https://doi.org/10.1080/00397910008087248>
  • Al-Zaydi Khadijah Mohamed, Al-Shiekh Mariam Abd Alha, Hafez Ebtisam Abdel-Aziz: Enaminonitriles in Heterocyclic Synthesis: New Routes for the Synthesis of Some Novel Azolo[1,5-a]pyrimidine, Pyrimido[1,2-a]benzimidazole, Pyrido[1,2-a]benimdazole, Pyrazolo[3,4-b]pyridine, Pyrazole and Pyrimidine Derivatives. Journal of Chemical Research 2000, 2000, 13. <https://doi.org/10.3184/030823400103165716>
  • Sayed Samia M., Raslan Mohamed A., Khalil Mohamed A., Dawood Kamal M.: Synthesis and reactivity of cyanomethyl 2-amino-4-methylthiazolyl ketone. A facile synthesis of novel pyrazolo[5,1-c]1,2,4-triazine, 1,2,4-triazolo[5,1-c]1,2,4-triazine, 1,2,4-triazino[4,3-a]benzimidazole, pyridazine-6-imine and 6-oxopyridazinone derivatives. Heteroatom Chem 1999, 10, 385. <https://doi.org/10.1002/(SICI)1098-1071(1999)10:5<385::AID-HC8>3.0.CO;2-O>
  • Dawood Kamal M., Kandeel Zaghloul E., Farag Ahmad M.: Heterocyclic synthesis via enaminones: Regioselective synthesis of some novel pyrazole, isoxazole, pyrimidine, pyrido[1,2-a]benzimidazole and pyrazolo[1,5-a]-pyrimidine derivatives. Heteroatom Chem 1999, 10, 417. <https://doi.org/10.1002/(SICI)1098-1071(1999)10:5<417::AID-HC12>3.0.CO;2-3>
  • Sayed Samia M., Raslan Mohamed A., Khalil Mohamed A., Dawood Kamal M.: Synthesis and reactivity of cyanomethyl 2-amino-4-methylthiazolyl ketone. A facile synthesis of novel pyrazolo[5,1-c]1,2,4-triazine, 1,2,4-triazolo[5,1-c]1,2,4-triazine, 1,2,4-triazino[4,3-a]benzimidazole, pyridazine-6-imine and 6-oxopyridazinone derivatives. Heteroatom Chem. 1999, 10, 385. <https://doi.org/10.1002/(SICI)1098-1071(1999)10:5<385::AID-HC8>3.0.CO;2-O>
  • Dawood Kamal M., Kandeel Zaghloul E., Farag Ahmad M.: Heterocyclic synthesis via enaminones: Regioselective synthesis of some novel pyrazole, isoxazole, pyrimidine, pyrido[1,2-a]benzimidazole and pyrazolo[1,5-a]-pyrimidine derivatives. Heteroatom Chem. 1999, 10, 417. <https://doi.org/10.1002/(SICI)1098-1071(1999)10:5<417::AID-HC12>3.0.CO;2-3>
  • Al-Mousawi Saleh M., Elkholy Yehia M., Mohammad Mohammad A., Elnagdi Mohammad H.: SYNTHESIS OF NEW CONDENSED 2-AMINO-4H-PYRAN-3-CARBONITRILES AND OF 2-AMINOQUINOLINE-3-CARBONITRILES. Org Prep Proced Int 1999, 31, 305. <https://doi.org/10.1080/00304949909458324>
  • Dawood Kamal M., Farag Ahmad M., Kandeel Zaghloul E.: Heterocyclic Synthesis via Enaminonitriles: One-pot Synthesis of Some New Pyrazole, Isoxazole, Pyrimidine, Pyrazolo[1,5-a]pyrimidine, Pyrimido[1,2-a]benzimidazole and Pyrido[1,2-a]benzimidazole Derivatives. Journal of Chemical Research 1999, 23, 88. <https://doi.org/10.1177/174751989902300211>
  • Sadek Kamal Usef, Selim Maghraby Ali, Elnagdi Mohamed Hilmy, Otto Hans Hartwig: Studies on Fused Azoles: Synthesis of Several New Polyfunctionally Substituted Fused Pyrazoles. Bulletin of the Chemical Society of Japan 1993, 66, 2927. <https://doi.org/10.1246/bcsj.66.2927>
  • ELNAGDI M. H., TAHA N. H., ABD EL ALL F. A. M., ABDEL‐MOTALEB R. M., MAHMOUD F. F.: ChemInform Abstract: Condensed Pyrazoles: Synthesis of New Methyl and Amino Pyrazolo(1,5‐a)pyrimidines and of Pyrazolo(5,1‐c) (1,2,4)triazines. ChemInform 1989, 20. <https://doi.org/10.1002/chin.198932205>