Collect. Czech. Chem. Commun. 1989, 54, 1082-1091

Studies on condensed pyrazoles: Synthesis of new methyl and amino pyrazolo[1,5-a]pyrimidines and of pyrazolo[5,1-c][1,2,4]triazines

Mohamed Hilmy Elnagdia, Nadia Hassen Tahab, Fatma Abdel Maksoud Abd El Alla, Ramadan Maawad Abdel-Motalebc and Fivian Farouk Mahmoudb

a Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt
b Department of Chemistry, Faculty of Science, El-Azhar University, Cairo, Egypt
c Department of Chemistry and Physics, Faculty of Education at Fayoum, Cairo University, Fayoum Egypt


A variety of 3-arylazo 5-amino and 7-aminopyrazolo[1,5-a]pyrimidines were obtained via reacting Ia-Id with cinnamonitriles. The structure of products was confirmed via 1H NMR. Both 5-amino- and 7-amino-3-arylazo pyrazolo[1,5-a]pyrimidines reacted, with protons in acetic acid-sulphuric acid mixture to yield the corresponding 3-unsubstituted acetylaminopyrazolo[1,5-a]pyrimidines. Diazotized Ia and Ib coupled with a variety of active methylene reagents to yield pyrazolo[5,1-c][1,2,4]triazines.