Collect. Czech. Chem. Commun. 1989, 54, 533-535

Mimicking bioactive peptides. [8-Nβ-Guanidoacetyl-α,β-diaminopropionic acid]vasopressin

Milan Zaorala and Viktor Krchňákb

a Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague 6
b Léčiva–Pharmaceuticals, 143 10 Prague 4


The title compound was prepared by solid phase methodology. It has 34.2 I.U./mg of pressor activity, 5.8 I.U./mg of uterotonic activity and by 3-4 orders of magnitude lower antidiuretic activity than DDAVP.