Collect. Czech. Chem. Commun. 1988, 53, 1943-1945

On the change of the order od stability of DNA base pairs as a result of the methylation of guanine

Pavel Hobzaa and Camille Sandorfyb

a Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague 6, Czechoslovakia
b Département de Chimie, Université de Montréal, Montréal, Canada H3C 3J7


The interaction of the 6-O methylguanine cation with cytosine and thymine was studied using the ab initio SCF method in combination with a London type expression for dispersion energy. The structure of the complex formed with cytosine differs from that found previously with guanine itself.