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Collect. Czech. Chem. Commun. 1988, 53, 2963-2985

Enzymes in preparative organic synthesis: The problem of increasing the yield of product

Anatolii N. Semenova, Václav Čeřovskýb, Mikhail I. Titova and Karel Martinekb

a Institute of Experimental Cardiology, U.S.S.R. Academy of Medical Sciences, 121552 Moscow, U.S.S.R.
b Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague 6, Czechoslovakia

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  • Levitsky Vladislav Yu., Lozano Pedro, Iborra José L.: Kinetic analysis of deactivation of immobilized α-chymotrypsin by water-miscible organic solvent in kyotorphin synthesis. Biotechnol Bioeng 1999, 65, 170. <<170::AID-BIT6>3.0.CO;2-Q>
  • Levitsky Vladislav Yu., Lozano Pedro, Iborra Jos� L.: Kinetic analysis of deactivation of immobilized ?-chymotrypsin by water-miscible organic solvent in kyotorphin synthesis. Biotechnol. Bioeng. 1999, 65, 170. <<170::AID-BIT6>3.0.CO;2-Q>
  • Ivanov Ivailo P., Kasche Volker, Petkov Dimiter D.: Thermodynamics of Enzymic Peptide Synthesis in Biphasic Aqueous–Organic Systems: Coupling of the Chemical and Phase Equilibria. Biocatalysis and Biotransformation 1996, 14, 181. <>
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  • Loos W. T., Geluk H. W., Ruijken M. M. A., Kruse C. G., Brussee J., Van Der Gen A.: Synthesis of Optically Active Cyanohydrins Using R-Oxynitrilase in a Liquid-Liquid Biphasic System: Part 1: An Industrially useful Procedure. Biocatalysis and Biotransformation 1995, 12, 255. <>
  • Halling Peter J.: Thermodynamic predictions for biocatalysis in nonconventional media: Theory, tests, and recommendations for experimental design and analysis. Enzyme Microbiology Technology 1994, 16, 178. <>
  • Hirata Makoto, Nemoto Katsumi, Hirata Akira: Solubility of Al (Benzyloxycarbonyl)-L-Aspartyl-L-Phenylalanine Methyl Ester Forming a Complex with L-Phenylalanine Methyl Ester in Aqueous System. J. Chem. Eng. Japan / JCEJ 1994, 27, 72. <>
  • Semenov A. N., Gachok A. P., Titov M. I., Martinek K.: Enzymes in preparative organic synthesis. Chemical equilibrium in countercurrent biphasic water-organic systems. Biotechnol Lett 1989, 11, 875. <>