Collect. Czech. Chem. Commun. 1987, 52, 1331-1339

Solvolysis of some 1-(8α-ergolinyl)-3,3-diethylureas and their salts

Antonín Černýa, Jan Beneša, Jaroslav Vacheka, Milan Pešáka, Josef Stuchlíkb, Milan Stuchlíkb, Petr Sedmerac, Miroslav Fliegerc and Jindřich Vokounc

a Research Institute for Pharmacy and Biochemistry, 130 60 Prague 3
b Galena, 747 70 Opava-Komárov
c Institute of Microbiology, Czechoslovak Academy of Sciences, 142 20 Prague 4


Nine salts of 1-(8α-ergolinyl)-3,3-diethylurea (II) were prepared and their solubility in water and the stability of the aqueous solutions at 60 and 100 °C were studied. The main product of hydrolysis is 6-methyl-8α-aminoergoline IV. The urethan VII is formed in the ethanolic solution. Both decomposition products are also formed under long-term storage at +5 °C. The course of hydrolysis of N-propyl homologue III is similar. The decomposition of 9,10-didehydro derivative I is much slower under the conditions used.