Collect. Czech. Chem. Commun. 1987, 52, 514-521

Peptides containing a neopentylglycine residue

Jan Pospíšek and Karel Bláha

Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague 6


Neopentylglycine (III, 2-amino-4,4-dimethylpentanoic acid) was synthesized in both enantiomeric forms. Using the conventional methods of peptide synthesis, L-prolyl-L-neopentylglycylglycine amide (VII), the diastereoisomeric cyclodipeptides cyclo(L-neopentylglycyl-L-prolyl) (IXa) and cyclo(D-neopentylglycyl-L-prolyl) (IXb) and also N-acetyl-L-neopentylglycine methylamide (X) were prepared as models for further studies on physical properties and conformation of peptides.