Collect. Czech. Chem. Commun. 1986, 51, 2466-2472

Polarographic and voltammetric determination of 6-mercaptopurine and 6-thioguanine

Jiří Barek, Antonín Berka, Ludmila Dempírová and Jiří Zima

Department of Analytical Chemistry, Charles University, 128 40 Prague 2


Conditions were found for the determination of 6-mercaptopurine (I) and 6-thioguanine (II) by TAST polarography, differential pulse polarography and fast-scan differential pulse voltammetry at a hanging mercury drop electrode. The detection limits were 10-6, 8 . 10-8, and 6 . 10-8 mol l-1, respectively. A further lowering of the detection limit to 2 . 10-8 mol l-1 was attained by preliminary accumulation of the determined substances at the surface of a hanging mercury drop.