Collect. Czech. Chem. Commun. 1985, 50, 2084-2088

Synthesis and biologic properties of an enkephalin analogue, a model substrate for enzymic conversion

Jaroslav Vičara, Martin Flegelb, Linda Hauzerovác, Tzezengijn Dashc, Karel Hauzerc and Tomislav Barthc

a Chemical Institute of Medical Faculty, Palacký University, 775 15 Olomouc
b Léčiva, 140 00 Prague 4
c Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague 6


An octapeptide analogue of Leu5-enkephalin, prolonged in the carboxyterminal part by the tripeptide Lys-Lys-Leu was prepared. Its action on guinea-pig ileum and splitting by trypsin and tissue cathepsin B was investigated.