Collect. Czech. Chem. Commun. 1985, 50, 280-285
https://doi.org/10.1135/cccc19850280

Structural analogues of 5,6-tetramethyleneuracil ribosides - Inhibitors of enzymes participating in nucleic acid synthesis

Marcin Dramińskia, Elżbieta Frassa, Janusz Gregerb and Krystyna Fabianowska-Majewskab

a Department of General Chemistry, Institute of Physiology and Biochemistry, Military School of Medicine, 906 47 Lodz, Poland
b Department of General Chemistry, Institute of Physiology and Biochemistry, School of Medicine, 901 31 Lodz, Poland

Abstract

1-N and 3-N ribosyl, allyl and (RS)-2',3'-dihydroxypropyl derivatives of 5,6-tetramethyleneuracil were prepared. Some of described compounds are inhibitors of enzymes involving in regulation of DNA synthesis.