Collect. Czech. Chem. Commun. 1985, 50, 103-113

Synthesis of new branched polypeptides with poly(lysine)back bone

Ferenc Hudecz and Mária Szekerke

Research Group for Peptide Chemistry, Hungarian Academy of Sciences, Budapest, Hungary


New analogues of branched polypeptides were synthesised for a further, more detailed study of the influence of the side chain terminating amino acids, particularly the hydrophobic character, configuration and the number of these amino acids, on the conformation and biological properties of the polymers. The following amino acids were coupled to poly(L-Lys-(DL-Alam)) in suitably protected and activated forms to study the above mentioned aspects: L-Nlc, L-Ile, L-Val, L-Phe, D-Phe, D-Leu, D-Tyr, D-His, L-Glu, D-Glu, L-Lys, D-Lys and additionally the L-Glu-L-Glu, D-Glu-D-Glu, L-Lys-L-Lys and D-Lys-D-Lys dipeptides. The deprotected and purified end products were freezedried and characterized by various methods.