Collect. Czech. Chem. Commun. 1984, 49, 1699-1712

Semisynthetic cephalosporines. Synthesis of some substituted tetrazolyl acetic and propionic acids

Ľubomír Jandaa, Zdeno Votickýb, Jozefína Jakubcováa, Jan Světlíka, Jaroslava Grimovác and Eva Maturovác

a Drug Research Institute, Modra, 811 04 Bratislava
b Institute of Chemistry, Slovak Academy of Sciences, 842 38 Bratislava
c Research Institute for Pharmacy and Biochemistry, 130 60 Prague


The N-alkylation of 5-[5-(substituted phenyl)-2-furyl]-1H-tetrazoles with ethyl bromoacetate or ethyl 3-bromopropionate afforded a mixture of 5-substituted ethyl 1- and 2-tetrazoyl acetates or propionates, which were separated and hydrolyzed to the corresponding 1- and 2-acetic or propionic acids, and used as intermediates for the synthesis of semisynthetic cephalosporine antibiotics. The prepared tetrazolyl acetic acids exhibited antiinflammatory activity.