Collect. Czech. Chem. Commun. 1984, 49, 1695-1698

Spectroscopic study of thiamine-phenylcarbamate complexes possessing local anaesthetic effect

Milan Remkoa, Tibor Liptajb, Juliana Veselovskác and Jozef Čižmárikc

a Faculty of Pharmacy, Comenius University, 832 32 Bratislava
b Central NMR Laboratory, Faculty of Chemical Technology, Slovak Institute of Technology, 880 37 Bratislava
c Chemical Institute, Comenius University, 832 32 Bratislava


UV and 1H NMR spectroscopy were used to study the interaction of thiamine with 1(2-(4-methoxyphenylcarbamoyl)ethyl) piperidinium chloride, a local anaesthetic drug. UV spectroscopy did not bring a direct evidence of the existence of a local anaesthetic-thiamine omplex. On the contrary, the upfield shifts of certain protons in the mixtures local anaesthetic with thiamine were interpreted as a result of a π-complex formation between the aromatic nucleus and the pyrimidine ring of thiamine