Collect. Czech. Chem. Commun.
1984, 49, 1695-1698
https://doi.org/10.1135/cccc19841695
Spectroscopic study of thiamine-phenylcarbamate complexes possessing local anaesthetic effect
Milan Remkoa, Tibor Liptajb, Juliana Veselovskác and Jozef Čižmárikc
a Faculty of Pharmacy, Comenius University, 832 32 Bratislava
b Central NMR Laboratory, Faculty of Chemical Technology, Slovak Institute of Technology, 880 37 Bratislava
c Chemical Institute, Comenius University, 832 32 Bratislava
Abstract
UV and 1H NMR spectroscopy were used to study the interaction of thiamine with 1(2-(4-methoxyphenylcarbamoyl)ethyl) piperidinium chloride, a local anaesthetic drug. UV spectroscopy did not bring a direct evidence of the existence of a local anaesthetic-thiamine omplex. On the contrary, the upfield shifts of certain protons in the mixtures local anaesthetic with thiamine were interpreted as a result of a π-complex formation between the aromatic nucleus and the pyrimidine ring of thiamine
