Collect. Czech. Chem. Commun. 1984, 49, 1311-1317

Structure of istanbulin A and istanbulin B - two sesquiterpenic lactones from Smyrnium olusatrum L.

Miloš Buděšínskýa, Miroslav Holuba, David Šamana, Zdenka Smítalováa, Ayhan Ulubelenb and Sevil Öksüzb

a Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague 6
b Faculty of Pharmacy, University of Istanbul, Turkey


The structures of istanbulin A (I) and istanbulin B (III), including absolute configurations, have been derived on the basis of spectral methods, primarily a detailed analysis of 1H NMR spectra and circular dichroism measurements. Both substances belong to the type of (4R, 5S,10R)-eremophilan-8,12-olides.