Collect. Czech. Chem. Commun. 1984, 49, 2562-2565

Enzymatic resolution of γ-carboxy-DL-glutamic acid

Václav Čeřovský and Karel Jošt

Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague 6


Optically active γ-carboxy-L-glutamic acid was prepared by enantioselective reaction of benzyloxycarbonyl-γ-carboxy-DL-glutamic acid with phenylhydrazine, catalyzed by papain (E.C., and subsequent removal of the protecting groups from the obtained benzyloxycarbonyl-γ-carboxy-L-glutamic acid α-phenylhydrazide.