Collect. Czech. Chem. Commun. 1984, 49, 2557-2561
https://doi.org/10.1135/cccc19842557

Papain-catalyzed synthesis of phenylhydrazides of N-acylamino acids

Václav Čeřovský and Karel Jošt

Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague 6

Abstract

Phenylhydrazides of Nα-acyl derivatives of all coded amino acids, except proline, were prepared by papain (E.C. 3.4.22.2)-catalyzed synthesis. Comparison of yields affords information about the suitability of the amino acid in position P1 in papain-catalyzed syntheses of peptides.