Collect. Czech. Chem. Commun. 1984, 49, 2557-2561

Papain-catalyzed synthesis of phenylhydrazides of N-acylamino acids

Václav Čeřovský and Karel Jošt

Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague 6


Phenylhydrazides of Nα-acyl derivatives of all coded amino acids, except proline, were prepared by papain (E.C. synthesis. Comparison of yields affords information about the suitability of the amino acid in position P1 in papain-catalyzed syntheses of peptides.