Collect. Czech. Chem. Commun. 1983, 48, 1489-1498

4-Thia-5-cholesten-3-one and some further steroidal δ-thioenol lactones

Alexander Kasal

Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague 6


δ-Oxo acids VI-IX and XIV were converted to δ-thioenol lactones X-XIII and XV on reaction with phosphorus pentasulfide in pyridine. Under these conditions the ε-oxo acid XVI affords B-norsteroids XVII and XVIII. The proposed structures are confirmed by a number of physico-chemical data. The reduction of these thienol lactones with hydrides is also described.