Collect. Czech. Chem. Commun. 1983, 48, 1483-1488

(5R,8S,10R)-6-Alkyl-8-ergolinecarboxylic acids and some of their derivatives

Antonín Černý, Viktor Zikán, Drahuše Vlčková, Jan Beneš, Jiří Holubek, Karel Řežábek, Marie Aušková and Jiří Křepelka

Research Institute for Pharmacy and Biochemistry, 130 60 Prague 3


(5R,8S,10R)-6-Methyl-8-methoxycarbonylergoline (VIIb) was converted via Ib and IIb into its 6-analogues IIIb-VIb, which, in turn, were converted into acids IIIa-VIa and hydrazides IIIc-VIc. Some of the esters prepared, mainly IVb, had inhibitory effects on the secretion of prolactin in rats.