Collect. Czech. Chem. Commun.
1983, 48, 292-298
https://doi.org/10.1135/cccc19830292
Substituted ω-(4-oxo-3,4-dihydro-5-pyrimidinyl) alkanoic acids, their derivatives and analogues
Miloš Beran, Antonín Černý, Jiří Křepelka and Jaroslav Vachek
Research Institute for Pharmacy and Biochemistry, 130 60 Prague 3
Abstract
Condensation of guanidine with diethyl 2-formylbutanedioate (XI), diethyl 2-cyanobutanedioate (XII), diethyl 2-cyanoheptanedioate (XIII), ethyl 6,6-dicyanohexanoate (XIV), or diethyl 6,6-dicyanoundecanedioate (XV), followed by hydrolysis of the esters formed, afforded the respective substituted ω-(2-amino-5-pyrimidinyl)alkanoic acids (II, V, VI, IX and X). Analogously, condensation of the ester XIII with urea or thiourea gave acids VII and VIII. The acid II was converted into its ethyl and butyl ester (III and IV, respectively). The compounds prepared showed no significant antineoplastic effects in mice with experimental tumours.
