Collect. Czech. Chem. Commun. 1983, 48, 299-303

Some derivatives of 4-[(2-amino-6-hydroxy-4-oxo-3,4-dihydro-5-pyrimidinyl)methyl] benzoic acid

Rudolf Kotva, Jaroslav Vachek and Jiří Křepelka

Research Institute for Pharmacy and Biochemistry 130 60 Prague 3


Esterification of the title acid (I) gave esters II - VI. Halogenation of the acid I afforded its 5-chloro and 5-bromo derivatives, VII and VIII. Condensation of triesters XIV - XVII and of tetraester XVIII with guanidine, followed by hydrolysis, led to acids IX - XIII. Some of these compounds had a weak antineoplastic activity in animals with experimental transplantable tumours.