Collect. Czech. Chem. Commun. 1982, 47, 2540-2560

Synthesis and properties of oxytocin analogues with high and selective natriuretic activity

Michal Lebla, Pavel Hrbasa, Jana Škopkováa, Jiřina Slaninováa, Alena Machováb, Tomislav Bartha and Karel Jošta

a Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague 6
b Research Institute for Pharmacy and Biochemistry, 194 04 Prague 9


Deamino-6-carba-oxytocin analogues with modified aromatic amino acid in the position 2 were prepared by stepwise peptide synthesis in solution and cyclization in the last step. Some of the prepared analogues exhibit high and/or specific natriuretic activity. Structural requirements for this type biologic activity are discussed.