Collect. Czech. Chem. Commun. 1982, 47, 1235-1239

2-Formyl derivatives of 6-methylergoline-I

Jan Beneš and Miroslav Semonský

Research Institute for Pharmacy and Biochemistry, 130 00 Prague 3


Reaction of ergoline derivatives I, III - VI with 2-alkoxy-1,3-dithiolan, generated in situ, gave the 2-(1,3-dithiolan-2-yl) derivatives VII, XI - XIV.Hydrolysis of the thioacetal group in these compounds produced 2-formylergoline derivatives, XV-XIX, which proved to have only a weak inhibitory effect on the secretion of prolactin.