Collect. Czech. Chem. Commun. 1982, 47, 1130-1138

Synthesis, IR spectra and antimicrobial activity of 1,4-dialkylpiperazine dioxides

Ferdinand Devínskýa, Ivan Lackoa, Dušan Mlynarčíkb and Ľudovít Krasneca

a Department of Inorganic and Organic Chemistry
b Department of Biochemistry and Microbiology, Faculty of Pharmacy, Comenius University, 832 32 Bratislava


Preparation of 1-alkylpiperazines, 1-alkyl-4-methylpiperazines, 1,4-dialkylpiperazines, 1-alkyl-4-methylpiperazine dioxides, and 1,4-dialkylpiperazine dioxides is described. IR spectra of dioxides were interpreted. Antimicrobial activity of dioxides against Staphylococcus aureus, Escherichia coli and Candida albicans was determined.