Collect. Czech. Chem. Commun. 1982, 47, 625-629

D-1-Carboxymethyl-8β-carboxy-6-methylergoline and some 1,8-disubstituted ergolines derived from it

Jan Šmidrkal and Miroslav Semonský

Research Institute for Pharmacy and Biochemistry, 130 60 Prague 3


Reaction of D-8β-carboxy-6-methylergoline (I) with ethyl bromo acetate gave D-1-carboxy-8β-carboxy-6-methylergoline (II), whose dimethyl ester III was reduced with sodium borohydride, either selectively to D-1-(2-hydroxyethyl)-8β-methoxycarbonyl-6-methylergoline (IV) or completely to D-1-(-2-hydroxyethyl)-8β-hydroxymethyl-6-methylergoline (V). Derivatives VI-XV of compounds IV and V have also been prepared.