Collect. Czech. Chem. Commun. 1982, 47, 622-624

Alkylation of ergoline derivatives at position N(1)

Jan Šmidrkal and Miroslav Semonský

Research Institute for Pharmacy and Biochemistry, 130 60 Prague 3


N(1)-Alkyl-8β-ergolines I-XII were prepared by alkylation of 8β-ergoline derivatives XIII to XVIII with alkyl halides in dimethyl sulphoxide in the presence of potassium hydroxide. The compounds I-XII exhibited weak inhibition effects on the secretion of prolactin