Collect. Czech. Chem. Commun.
1982, 47, 2746-2748
https://doi.org/10.1135/cccc19822746
Oxidation mechanism of carcinogenic bis-azo dyestuff Trypan Blue
Miroslav Matrka and Jana Pípalová
Department of Toxicology, Research Institute of Organic Syntheses, 532 18 Pardubice-Rybitví
Abstract
Oxidation of Trypan Blue with cerium(IV) ion in acid medium gives arenediazonium cation similar to the oxidation product of N,N-dimethyl-4-aminoazobenzene. Quantitative evaluation of the arenediazonium salt formed has been carried out spectrophotometrically after previous C-azo coupling with 2-naphthol.
