Collect. Czech. Chem. Commun. 1981, 46, 1530-1533

Esters of 1-[4,4-bis(4-fluorophenyl)butyl]-4-(4-chloro-3-trifluoromethylphenyl)-4-piperidinol

Miroslav Rajšner, Antonín Dlabač and Miroslav Protiva

Research Institute for Pharmacy and Biochemistry, 130 60 Prague 3


1-[4,4-Bis(4-fluorophenyl)butyl]-4-(4-chloro-3-trifluoromethylphenyl)-4-piperidinol (I) was transformed by reactions with acetyl chloride, decanoyl chloride and 3,4,5-trimethoxybenzoyl chloride to the esters II-IV. The acetate II, administered orally, was compared with the amino alcohol I in the tests of antiapomorphine actions in rats and dogs and was found inactive. The decanoate III, which was administered intramuscularly to dogs, proved properties of an ultra-long-acting depot neuroleptic.