Collect. Czech. Chem. Commun. 1981, 46, 1523-1529

Some derivatives of 4-aryl-2,3-dicyano-1-naphthol

Jiří Křepelka, Iva Vančurová and Jiří Holubek

Research Institute for Pharmacy and Biochemistry, 130 60 Prague 3


Reactions of vicinal aromatic dibromo derivatives Ia-d with the system copper(I) cyanide-tetramethylurea gave the vicinal dicyano derivatives IIa-d; products of partial substitution, Va-d, demethylation and deacetylation, IIIa-c, were also formed. The compounds IIIa-c were also prepared by direct demethylation of compounds IIa-c with the system anhydrous aluminium chloride-dichloroethane. The structures of selected compounds were determined by spectral methods. Compounds IIa-d have proved to have a moderate antineoplastic effect in animals with some transplantable experimental tumours.