Collect. Czech. Chem. Commun.
1981, 46, 1530-1533
https://doi.org/10.1135/cccc19811530
Esters of 1-[4,4-bis(4-fluorophenyl)butyl]-4-(4-chloro-3-trifluoromethylphenyl)-4-piperidinol
Miroslav Rajšner, Antonín Dlabač and Miroslav Protiva
Research Institute for Pharmacy and Biochemistry, 130 60 Prague 3
Abstract
1-[4,4-Bis(4-fluorophenyl)butyl]-4-(4-chloro-3-trifluoromethylphenyl)-4-piperidinol (I) was transformed by reactions with acetyl chloride, decanoyl chloride and 3,4,5-trimethoxybenzoyl chloride to the esters II-IV. The acetate II, administered orally, was compared with the amino alcohol I in the tests of antiapomorphine actions in rats and dogs and was found inactive. The decanoate III, which was administered intramuscularly to dogs, proved properties of an ultra-long-acting depot neuroleptic.
