Collect. Czech. Chem. Commun. 1981, 46, 781-791

Potential noncataleptic neuroleptic agents: 2,4-Dichloro- and 2,4,8-trichloro-10-piperazino-10,11-dihydrodibenzo[b,f]thiepins

Vladimír Valenta, Antonín Dlabač and Miroslav Protiva

Research Institute for Pharmacy and Biochemistry, 130 60 Prague 3


3,5-Dichloro-2-iodobenzoic acid (IV), prepared from 3,5-dichloroanthranilic acid (III), was transformed in 5 steps into the diphenyl sulfide-2-acetic acids IXab. Cyclization resulted in ketones XVab which were processed in further 3 steps into the title compounds Iab and IIa. These products are mild tranquilizers devoid of cataleptic and antiapomorphine activity.