Collect. Czech. Chem. Commun. 1980, 45, 1305-1314

Synthesis of the amino-terminal decapeptide of human calcitonin, in which the disulfide bond is replaced by a thioether group

Zdenko Procházka and Karel Jošt

Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague 6


A fully protected amino-terminal decapeptide Ib with the sequence of human calcitonin, in which the S-S bridge was replaced by the S-CH2 group (a so-called 7-carba-analogue), was synthetized mainly by the stepwise method. The cyclization of the linear decapeptide was performed by means of active ester.