Collect. Czech. Chem. Commun. 1980, 45, 941-949

Conformation of branched polypeptides based on poly(L-lysine): Circular dichroism study

Hana Votavováa, Ferenc Hudeczb, Judit Kajtárb, Mária Szekerkeb, Jaroslav Šponara and Karel Bláhaa

a Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague 6, Czechoslovakia
b Research Group for Peptide Chemistry, Hungarian Academy of Sciences, Budapest, Hungary


Circular dichroism (CD) spectra of branched (multichain) polypeptides based on poly(L-lysine) with DL-alanine and other amino-acid residues in the side chain have been measured under various conditions of pH. The spectra were interpreted using spectra of poly(L-lysine) as standard. No straightforward correlation between polypeptide CD spectra and their structure could be detected. The contribution of the side chain CD to that of the main chain is additive in some cases, but in other cases qualitatively different CD spectra arise. The reason for this CD behavior is discussed.