Collect. Czech. Chem. Commun. 1980, 45, 3045-3050

Biological activities and protracted action of carba-analogues of deamino-oxytocin with O-methyltyrosine in position 2

Tomislav Barth, Jiřina Slaninová, Michal Lebl and Karel Jošt

Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague 6


The biological potency and the duration of the effect of two analogues of deamino-oxytocin, having the disulfide bond substituted by a thioether group and the tyrosine residue replaced by O-methyltyrosine, were compared in the uterotonic and galactogogic assay in vivo. [2-O-Methyltyrosine]deamino-6-carba-oxytocin had a very low formal elimination constant (i.e. strongly protracted action) in the uterotonic assay.