Collect. Czech. Chem. Commun. 1980, 45, 3039-3044

Inhibition of S-adenosyl-L-homocysteine hydrolase by the aliphatic nucleoside analogue - 9-(S)-(2,3-dihydroxypropyl)adenine

Ivan Votruba and Antonín Holý

Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague 6


9-(S)-(2,3-Dihydroxypropyl)adenine, a nucleoside analogue with antiviral activity, inhibits the hydrolysis of S-adenosyl-L-homocysteine catalyzed by rat liver S-adenosyl-L-homocysteine hydrolase (Ki = 3.5 μM; Ki/Km = 5.6 . 10-2). The effect upon the synthesis of the substrate is much less pronounced.