Collect. Czech. Chem. Commun. 1979, 44, 269-274

Synthesis of 5-methyl-2H-1,3-oxazine-2,4(3H)-dione

Jiří Farkaš

Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague 6


The title compound (II) was prepared by acid-catalysed hydrolysis of N,N-disubstituted β-methoxy-α-methylacryloylureas V-VIII. This reaction is accompanied by the parallel cleavage of the amide bond in the compounds V-VII leading to N,N-disubstituted ureas and α-formylpropionic acid.