Collect. Czech. Chem. Commun. 1979, 44, 260-268

Preparation of some 3α,5-cycloandrostane derivatives with expanded ring B

Helena Velgová, Miroslava Synáčková and Václav Černý

Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague 6


Reaction of 17β-hydroxy-3α,5-cyclo-5α-androstan-6-one-17-benzoate (II) with diazomethane is reported. From the complex reaction mixture compounds with eight-, nine- and ten-membered ring B were isolated. Their structures were established by means of spectroscopic methods. Some derivatives of these compounds are described.