Collect. Czech. Chem. Commun. 1950, 15, 1-16

Electrophoresis of proteins in agar jelly

A. H. Gordon, B. Keil, K. Šebesta, O. Knessl and F. Šorm


The reduction of toluenesulphonyl-L-pyrrolidonecarboxamide (II) and the corresponding anilide (III) with lithium borohydride yields the amide and anilide of N-toluenesulphonyl-δ-hydroxy-L-α-aminovaleric acid (IV and V), respectively. Cyclisation of these compounds leads to the corresponding derivatives of toluenesulphonyl-L-proline which have been converted to L-proline. These reactions represent the first direct chemical conversion of L-glutamic acid to L-proline.