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1999, Volume 2, Collection Symposium Series

ISBN	80-86241-04-1

Conference

Title	XIth Symposium on Chemistry of Nucleic Acid Components
Location	Špindlerův Mlýn
Date	4 Sep 1999 – 9 Sep 1999

Articles

• pp. 1-5
  Mohamed I. Elzagheid, Esa Mäki, Ulla Kaukinen, Mikko Oivanen and Harri Lönnberg Hydrolysis and intramolecular transesterification of 3'-thioinosine 3'-S-phosphorothiolate triester
• pp. 6-10
  Satu Mikkola, Izabela Zagorowska and Harri Lönnberg The effect of the secondary structure of RNA on the reactivity of its phosphodiester bonds: The cleavage of phosphodiester bonds within hairpin loops in the presence and absence of metal ion catalysts
• pp. 11-14
  Jörg Parsch and Joachim W. Engels C–F···H–C hydrogen bonds in crystals of fluorobenzene ribonucleosides
• pp. 15-21
  Uwe Parsch and Joachim W. Engels Calculation of thermodynamic data from UV melting curves of triple helical nucleic acids: A comparison of methods
• pp. 22-26
  Ekaterina V. Efimtseva, Andrei A. Rodionov, Georgii V. Bobkov, Boris S. Ermolinsky, Marina V. Fomitcheva, Sergey N. Mikhailov and Piet Herdewijn Studies on disaccharide nucleoside synthesis
• pp. 27-30
  Michal Hocek, Martina Havelková, Dalimil Dvořák, Antonín Holý and Ivan Votruba Synthesis of 6-phenylpurine bases and nucleosides by Suzuki–Miyaura cross-coupling reactions of 6-chloropurines with substituted phenylboronic acids
• pp. 31-34
  Joanna Zeidler 7-Alkynylation of tricyclic analogues of acyclovir by the Sonogashira reaction
• pp. 35-38
  Sarah E. Lee, Nathalie Mignet, Joseph S. Vyle, Louise Whetton, Jane A. Grasby and David M. Williams The synthesis of modified 5-(aminoalkyl)- and 5-(aminoalkenyl)uridine 5'-triphosphates
• pp. 39-42
  Helmars Smits, Māris Turks, Dace Katkevica and Ērika Bizdēna Synthesis of protected 3,5-dideoxy-3-C-azidomethyl-D-allofuranose, precursor of 3',5'-C-modified nucleoside analogs
• pp. 43-46
  Jerzy Boryski Synthesis of novel analogs of acyclovir modified in the side-chain portion by reaction of guanosine with 1,3-dioxolanes
• pp. 47-52
  Mrinal K. Kundu, András Földesi and Jyoti Chattopadhyaya Synthesis of C2-d₁-2,3-O-isopropylidene-D-ribose
• pp. 53-56
  Igor A. Mikhailopulo and Grigorii G. Sivets Synthesis of peracylated derivatives of L-ribofuranose from D-ribose and their use for the preparation of β-L-ribonucleosides
• pp. 57-59
  Miroslav Otmar, Milena Masojídková and Antonín Holý Synthesis of acyclic 9-deazanucleosides: 9-(2,3-Dihydroxypropyl)-9-deazahypoxanthine
• pp. 60-62
  Markéta Rinnová and Ivan Rosenberg 3'-N-phosphonomethyl derivatives of pyrrolidine nucleosides related to L-nucleotides
• pp. 63-68
  Jacek Cieślak, Jadwiga Jankowska, Michał Sobkowski, Annika Kers, Inger Kers, Jacek Stawinski and Adam Kraszewski The reactions of aryl nucleoside H-phosphonates with O-, N-, and S-nucleophiles
• pp. 69-74
  Annika Kers, Inger Kers, Jacek Stawinski, Jacek Cieślak, Jadwiga Jankowska and Adam Kraszewski Developing synthetic methods for nucleotide analogues. A progress report
• pp. 75-78
  Tommy Johansson, Martin Bollmark and Jacek Stawinski Studies on sulfurisation of H-phosphonate diesters in the presence of diazabicyclo[5.4.0]undec-7-ene (DBU)
• pp. 79-82
  Przemysław Godzina and Wojciech T. Markiewicz Synthetic oligonucleotide combinatorial libraries. 4. Synthesis of 5-polyaminomethyl-2'-deoxyuridines
• pp. 83-88
  G. Michael Blackburn, Andrzej Guranowski and Xiaohai Liu Ligand recognition in Fhit binding and cleavage of diadenosine polyphosphates
• pp. 89-91
  Šárka Králíková, Miloš Buděšínský, Milena Masojídková, Ivana Kavenová and Ivan Rosenberg Synthesis of α-hydroxyphosphonate analogs of ApA and UV spectroscopy study on their complexes with poly(U)
• pp. 92-95
  Dominik Rejman and Ivan Rosenberg Preparation of phosphonate monomers for phosphotriester solid-phase synthesis of isopolar nonisosteric oligonucleotide analogs
• pp. 96-99
  Dominik Rejman, Radek Liboska, Magdalena Endová, Ivana Kavenová, Zdeněk Točík and Ivan Rosenberg Synthesis and hybridization properties of isopolar, nonisosteric phosphonate-based homooligonucleotides
• pp. 100-104
  Arthur Van Aerschot, Yuris Maurinsh, Brigitte Allart, Valerie Boudou and Piet Herdewijn Analogues of hexitol nucleic acids: Structure function relationship of a new steric blocking agent
• pp. 105-108
  Yoshihiro Hayakawa, Akira Sakakura, Sophie B. Heidenhain and Masanori Kataoka A facile solid-phase synthesis of oligodeoxyribonucleotides and their amino acid conjugates via the allyl-protected phosphoramidite approach with benzimidazolium triflate as a promoter
• pp. 109-113
  Zdeněk Točík, Ivana Kavenová and Ivan Rosenberg Synthetic route to novel isosteric phosphonate analogs of oligonucleotides
• pp. 114-118
  Shigeki Sasaki, Fumi Nagatsugi and Minoru Maeda 2'-Deoxynucleoside derivatives of 6-substituted 2-aminopurine as highly efficient and selective cross-linking agent to cytidine
• pp. 119-123
  Stephen C. Holmes, Neil D. Pearson and Jane A. Grasby Synthesis and incorporation of a novel nucleoside phosphoramidite linker into oligonucleotides
• pp. 124-128
  Frank Seela, Tamizi Sugiyama, Enno Schweinberger and Helmut Rosemeyer Synthesis, base pairing and stacking properties of oligonucleotides containing 2-aza-2'-deoxyadenosine
• pp. 129-134
  Alex Azhayev Universal solid supports for oligonucleotide synthesis
• pp. 135-140
  François Morvan, Eric Vives, Jean-Charles Bologna, Christelle Dell’Aquila, Thierry Lioux, Jean-Jacques Vasseur, Isabelle Lefebvre, Bernard Rayner and Jean-Louis Imbach Synthesis of fluorescent labeled lipophilic prooligonucleotides and their rapid and efficient uptake in HeLa cells
• pp. 141-144
  Sergei N. Mikhailov, Boris S. Ermolinsky, Ekaterina V. Efimtseva, G. P. Moiseyev, V. L. Tunitskaya, E. E. Rusakova, S. N. Kochetkov, Oksana M. Gritsenko, Elezaveta S. Gromova, Arthur Van Aerschot and Piet Herdewijn Oligonucleotides containing hexapyranosyl nucleosides and disaccharide nucleosides: Synthesis, incorporation of dialdehyde groups and use as affinity reagents
• pp. 145-150
  Nikolai N. Polushin Synthesis of highly functionalized oligonucleotides using novel modifying and branching phosphoramidite units
• pp. 151-155
  Arthur Van Aerschot, Mark Vandermeeren, Johan Geysen, Walter Luyten, Marc Miller, David Atkins, Sonia Preveral, Ester Saison-Behmoaras and Piet Herdewijn In vitro evaluation of hexitol nucleic acid antisense oligonucleotides
• pp. 156-160
  Karen Vastmans, Luk Kerremans, Chris Hendrix, Arthur Van Aerschot, Sylvie Pochet, Philippe Marlière and Piet Herdewijn Recognition of 1,5-anhydrohexitol adenine triphosphate by a DNA polymerase
• pp. 161-167
  Timothy J. Pickering, Scott J. Garforth, Jon R. Sayers and Jane A. Grasby Mechanistic studies of a 5' nuclease from T5 bacteriophage
• pp. 168-174
  Andrey Arzumanov and Michael J. Gait Inhibition of the HIV-1 Tat protein-TAR RNA interaction by 2'-O-methyl oligoribonucleotides
• pp. 175-179
  Hikoya Hayatsu, Sanae Mimaki, Nao Ishizaki, Keiji Wakabayashi and Chitose Sugiyama Copper phthalocyanine-chitin, an adsorbent for carcinogen–nucleotide adducts
• pp. 180-185
  Zdeněk Zídek, Antonín Holý, Daniela Franková, Evžen Buchar and Zdeněk Jiřička Inhibition of rat adjuvant-induced arthritis by 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA; Adefovir): Immunological, biochemical and hematological correlates
• pp. 186-190
  Zbigniew J. Lesnikowski and Marzena Przepiórkiewicz An effect of stereochemistry on transport of tetra(thymidine methylphosphonate) across organic liquid barrier
• pp. 191-196
  Tadeusz Kuliński, Łukasz Bielecki, Mikołaj Olejniczak, Izabela Zagorowska and Ryszard W. Adamiak Structure and dynamics of the apical loop region of 29-mer hairpin of the TAR RNA HIV-1 sequence
• pp. 197-202
  Christian Schmidt, Rüdiger Welz and Sabine Müller Ribozyme mediated RNA double cleavage
• pp. 203-208
  Beate Scholz, Christian Schmidt, Rüdiger Welz and Sabine Müller Fast quantitative assay of hairpin ribozyme activity based on DNA sequencer technology
• pp. 209-212
  Victoria H. Harris, Alan Hamilton, David M. Williams and David P. Hornby Studying the function of methyltransferases using nucleotide analogue based random mutagenesis
• pp. 213-213
  Marek Kwiatkowski, Simon Fredriksson, Anders Isaksson, Mats Nilsson and Ulf Landegren In situ reversal of oligonucleotide orientation
• pp. 214-218
  Anna Niedzwiecka-Kornas, Lidia Chlebicka, Janusz Stępiński, Marzena Jankowska-Anyszka, Zbigniew Wieczorek, Edward Darżynkiewicz, Robert E. Rhoads and Ryszard Stolarski Spectroscopic studies on association of mRNA cap-analogues with human translation factor eIF4E. From modelling of interactions to inhibitory properties
• pp. 219-221
  Erkki J. Nurminen, Jorma K. Mattinen and Harri Lönnberg Catalysis in tetrazole-promoted phosphoramidite alcoholysis
• pp. 222-224
  Qi Wang, Satu Mikkola, Zoltan Jori, Mia Helkearo and Harri Lönnberg Bimetallic Ca²⁺ and Zn²⁺ complexes of BISDIEN: Potential catalysts of RNA cleavage
• pp. 225-227
  Mohamed I. Elzagheid, Kati Mattila, Mikko Oivanen, Bryan C. N. M. Jones, Richard Cosstick and Harri Lönnberg Hydrolytic reactions of 2',3'-dideoxy-3'-thiothymidine 3',5'-cyclic phosphorothiolate methyl ester
• pp. 228-229
  Niangoran Koissi, Kari Neuvonen, Tony Munter, Leif Kronberg and Harri Lönnberg A novel fluorescent base modification by reaction of guanosine with triformylmethane
• pp. 230-232
  Mikko Ora, Johanna Järvi, Mikko Oivanen and Harri Lönnberg Hydrolytic reactions of the phosphorodithioate analog of uridylyl(3',5')uridine: Cleavage, desulfurization and isomerization
• pp. 233-236
  Jana Zachová, Ivana Císařová, Miloš Buděšínský, Radek Liboska, Zdeněk Točík and Ivan Rosenberg Crystal and solution structure of 5'-O-(guanosine-2'-O-phosphonomethyl)cytidine, an isopolar nonisosteric phosphonate analog of GpC
• pp. 237-241
  Tomasz Ostrowski, Joanna Zeidler, Tomasz Goslinski and Bozenna Golankiewicz Aralkylation reactions of 3,9-dihydro-3-R¹-6-R²-9-oxo-5H-imidazo[ 1,2-a]purines directed by substituents in 3 and 6 positions
• pp. 242-244
  Jerzy Boryski and Tomasz Zandecki Transglycosylation as a synthetic route towards 2'-deoxy-β-D-ribonucleosides
• pp. 245-247
  Krzysztof Felczak, Agnieszka Miazga and Tadeusz Kulikowski Synthesis of novel acyclo 6-phenylselenenyluracils – potential selective anti-HIV agents
• pp. 248-251
  Alois Pískala, Naeem B. Hanna, Milena Masojídková, Miroslav Otmar and Pavel Fiedler Synthesis of N⁴-alkyl-5-azacytidines and their base pairing with carbamoylguanidines – a contribution to explanation of the mutagenicity of 5-aza-2'-deoxycytidine
• pp. 252-254
  Miroslav Otmar, Ivan Votruba and Antonín Holý An alternative synthesis of HPMPC and HPMPA diphosphoryl derivatives
• pp. 255-256
  Michal Česnek, Michal Hocek and Antonín Holý Cross-coupling reactions of 2-amino-6-halopurine derivatives with organometallic reagents leading to 6-alkylated purine acyclic nucleotide analogues
• pp. 257-259
  Dana Hocková, Milena Masojídková and Antonín Holý Significant influence of (N,N-dimethylamino)methylene protection at N⁶-position of adenine on regioselectivity of alkylations: Selective synthesis of 7-substituted adenines
• pp. 260-262
  Zlatko Janeba and Antonín Holý Synthesis of 8-hydroxy and 8-mercapto derivatives of acyclic adenine nucleoside and nucleotide analogs. Alkylation of 8-substituted adenines
• pp. 263-265
  Petr Alexander, Antonín Holý and Milena Masojídková Synthesis of N3-substituted isoguanine derivatives of acyclic nucleotide phosphonates
• pp. 266-267
  Hubert Hřebabecký Synthesis of carba analogues of 2'-deoxy-4'-C-(hydroxymethyl)nucleosides
• pp. 268-272
  Māris Turks, Dace Katkevica, Helmars Smits and Ērika Bizdēna A convenient synthesis of new sugar amino acid: 3-Aminomethyl-3-deoxy-1,2-O-isopropylidene-α-D-ribo-hexofuranuronic acid
• pp. 273-276
  Serge Van Calenbergh, Andreas Link, Shelly Fujikawa, Veerle Vanheusden, Denis De Keukeleire, Adriaan P. Ijzerman and Piet Herdewijn 5'-Deoxy congeners of 9-(3-amido-3-deoxy-β-D-xylofuranosyl)-N⁶-cyclopentyladenine: New adenosine A₁ receptor antagonists
• pp. 277-280
  David F. Ewing, Nour-Eddinef Ahmi and Grahame Mackenzie Synthesis of nucleoside analogues incorporating the 3-hydroxymethylphenyl glycone; a new approach to conformationally restricted systems for enzyme inhibition
• pp. 281-282
  Martina Pressová, Miloš Buděšínský and Ivan Rosenberg Spontaneous oligomerization of imidazolidate of 5'-O-phosphonomethyladenosine
• pp. 283-285
  Katarzyna Adrych-Rożek, Wojciech T. Markiewicz, Agata Jagiełło, Grażyna Płucienniczak, Andrzej Płucienniczak and Maria Markiewicz Synthesis of oligodeoxynucleotides comprising N-6 methylated adenine and its detection within a nucleotide sequence
• pp. 286-288
  Romana Krejčová, Květoslava Horská, Ivan Votruba and Antonín Holý Phosphorylation of enantiomers of HPMPG
• pp. 289-293
  Gabriel Birkuš, Ivan Votruba, Antonín Holý and Berta Otová HPMPApp as a substrate toward replicative DNA polymerases α, δ and ε
• pp. 294-297
  Maxim Antopolsky, Elena Azhayeva, Unni Tengvall and Alex Azhayev General method to synthesize disulfide cross-linked peptide-oligonucleotide phosphorothioate conjugates
• pp. 298-301
  Thorsten Strube and Joachim W. Engels Synthesis and thermodynamic properties of different 2'-fluoro modified UUCG hairpin loops
• pp. 302-305
  Thomas J. Lehmann, Karin Schwarzer, Markus Schweitzer and Joachim W. Engels Thermodynamic and CD-spectroscopic characterization of self-complementary methyl- and benzyl-modified d(CGCpGCG)-hexamers
• pp. 306-309
  Isabel K. McDonald, Stephen C. Holmes, Karen J. Young, Joseph S. Vyle, Timothy J. Pickering and Jane A. Grasby Functional group mutagenesis of the hairpin ribozyme
• pp. 310-312
  Dominiquer Askin, Inge Smits, Guy Schepers, Arthur Van Aerschot, Patrick Augustijns and Piet Herdewijn Synthesis of 3'- and 5'-cholesterol conjugates of oligonucleotides for improving cellular uptake
• pp. 313-315
  Eckhard Birch-Hirschfeld, Axel Walter, Anna Gabrielyan, Axel Stelzner, Hartmut Fritzsche and Holger Schütz A new parallel triplex motif: sequence dependence of thermal stability
• pp. 316-319
  Frank Seela and Harald Debelak Parallel-stranded DNA formed by 1-deazaadenine, 3-deazaadenine or 7-deazaguanine homo base pairs incorporated in the duplex of 5'-d[(G-A)₇-G]
• pp. 320-323
  Frank Seela and Georg Becher Oligonucleotides containing the pyrazolo[3,4-d]pyrimidine analogue of 2-aminopurine: duplexes with parallel and antiparallel chain orientation
• pp. 324-327
  Peter Leonard, Tomasz Ostrowski, Bozenna Golankiewicz and Frank Seela The isomerization of 2'-deoxyguanosine and the incorporation of guanine N⁷-(2'-deoxy-β-D-ribonucleoside) into oligonucleotide duplexes
• pp. 328-330
  A. J. Małkiewicz, M. Marszałek, A. B. Miśkiewicz, E. Sochacka, R. Guenther and P. F. Agris Site-specifically modified sequences of human tRNA₃^Lys and E. coli tRNA^Lys anticodon arms: synthesis and binding to ribosome
• pp. 331-334
  Rüdiger Welz, Beate Scholz, Christian Schmidt and Sabine Müller The hairpin ribozyme as a three-way junction

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