Collection Symposium Series 2011, 12, 349-350
https://doi.org/10.1135/css201112349
Published online 2015-08-20 10:18:34

Chemical synthesis of prodrugs derived from 5,6-dihydro-5-azacytosine and its nucleosides using vinyl esters

Lucie Janská, Jiří Blažek, David Mařák, Miroslav Otmar and Marcela Krečmerová

Individual author index pages


Other CCCC articles of these authors

  • Miroslav Otmar, Ivan Votruba and Antonín Holý
    An alternative synthesis of HPMPC and HPMPA diphosphoryl derivatives
    Symposium Series 1999, Vol. 2, pp. 252–254 [Abstract]
    Published online 2016-05-08 23:31:40
  • Alois Pískala, Naeem B. Hanna, Milena Masojídková, Miroslav Otmar and Pavel Fiedler
    Synthesis of N4-alkyl-5-azacytidines and their base pairing with carbamoylguanidines – a contribution to explanation of the mutagenicity of 5-aza-2'-deoxycytidine
    Symposium Series 1999, Vol. 2, pp. 248–251 [Abstract]
    Published online 2016-05-08 23:31:28
  • Miroslav Otmar, Milena Masojídková and Antonín Holý
    Synthesis of acyclic 9-deazanucleosides: 9-(2,3-Dihydroxypropyl)-9-deazahypoxanthine
    Symposium Series 1999, Vol. 2, pp. 57–59 [Abstract]
    Published online 2016-05-08 20:40:59
  • Marcela Krečmerová, Miloš Buděšínský and Antonín Holý
    Synthesis of optically pure N6-alkyl derivatives of (2R)-3-(adenin-9-yl)-2-hydroxypropanoic acid and related compounds
    Symposium Series 2002, Vol. 5, pp. 358–360 [Abstract]
    Published online 2016-01-25 20:50:59
  • Petr Čapek, Miroslav Otmar, Milena Masojídková and Antonín Holý
    Cross-coupling reactions of 2,6-dichloro-9-deazapurine
    Symposium Series 2002, Vol. 5, pp. 304–305 [Abstract]
    Published online 2016-01-25 20:41:51
  • Miroslav Otmar, Milena Masojídková, Ivan Votruba and Antonín Holý
    Synthesis and cytostatic activity of 2,6-diamino-9-benzyl-9-deazapurine and related compounds
    Symposium Series 2002, Vol. 5, pp. 38–39 [Abstract]
    Published online 2016-01-25 20:38:21
  • Marcela Krečmerová and Antonín Holý
    Synthesis of C-5 substituted HPMPC (cidofovir) derivatives
    Symposium Series 2005, Vol. 7, pp. 287–290 [Abstract]
    Published online 2015-11-08 11:54:07
  • Miroslav Otmar, Milena Masojídková and Antonín Holý
    Acyclic nucleoside phosphonates containing O-substituted hydroxypyridineamines and diamines as nucleobases
    Symposium Series 2005, Vol. 7, pp. 283–285 [Abstract]
    Published online 2015-11-08 11:54:02
  • David Mařák, Miroslav Otmar, Martin Dračínský, Ivan Votruba and Antonín Holý
    Nucleosides and nucleotides containing 8-aza-7,9-dideazaxanthine
    Symposium Series 2008, Vol. 10, pp. 426–428 [Abstract]
    Published online 2015-10-30 18:44:11
  • Martin Dračínský, Marcela Krečmerová and Antonín Holý
    Study of chemical stability of antivirally active 5-azacytosine acyclic nucleoside phosphonates using NMR spectroscopy
    Symposium Series 2008, Vol. 10, pp. 338–340 [Abstract]
    Published online 2015-10-30 18:41:11
  • Jiří Blažek, Antonín Holý, Petra Lipovová, Zita Purkrtová and Blanka Králová
    Analogs of pyrimidin-2-one nucleosides and their enzymatic galactosylation
    Symposium Series 2008, Vol. 10, pp. 322–324 [Abstract]
    Published online 2015-10-30 18:40:37
  • Marcela Krečmerová, Antonín Holý, Alois Pískala, Graciela Andrei, Robert Snoeck, Jan Balzarini and Erik De Clercq
    New antiviral agent, 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: esters and base-modified derivatives
    Symposium Series 2008, Vol. 10, pp. 196–200 [Abstract]
    Published online 2015-10-30 18:37:33
  • Tomáš Tichý, Graciela Andrei, Martin Dračínský, Antonín Holý, Jan Balzarini, Robert Snoeck and Marcela Krečmerová
    New amphiphilic prodrugs of adefovir and cidofovir
    Symposium Series 2011, Vol. 12, pp. 477–479 [Abstract]
    Published online 2015-08-20 10:25:04
  • Karel Pomeisl, Antonín Holý and Marcela Krečmerová
    Use of 1,3-dioxolanes in the syntheses of α-branched alkyl and aryl N-9-[2-(phosphonomethoxy)ethyl]purines
    Symposium Series 2011, Vol. 12, pp. 438–440 [Abstract]
    Published online 2015-08-20 10:23:40
  • David Mařák, Miroslav Otmar, Martin Dračínský and Marcela Krečmerová
    Nucleosides containing 8-aza-7,9-dideazaxanthine
    Symposium Series 2011, Vol. 12, pp. 383–385 [Abstract]
    Published online 2015-08-20 10:19:50
  • Marcela Krečmerová, Antonín Holý, Dana Hocková, Martin Dračínský, Dianne T. Keough and Luke W. Guddat
    9-[2-Hydroxy-3-(phosphonomethoxy)propyl] ("iso-HPMP") derivatives of purine bases and their side-chain modified analogues: synthesis and antimalarial activity
    Symposium Series 2011, Vol. 12, pp. 381–382 [Abstract]
    Published online 2015-08-20 10:19:45
  • Jiří Blažek, Martin M. Kaiser, Marie Zarevúcka, Blanka Králová and Marcela Krečmerová
    Enzymatic synthesis of ester prodrugs of DHPA and related compounds by lipases
    Symposium Series 2011, Vol. 12, pp. 307–309 [Abstract]
    Published online 2015-08-20 10:11:55
  • Dana Hocková, Antonín Holý, Michal Česnek, Ondřej Baszczyňski, Tomáš Tichý, Marcela Krečmerová, Zlatko Janeba, Tina S. Skinner-Adams, Lieve Naesens, Dianne T. Keoughd, John de Jersey and Luke W. Guddat
    Acyclic nucleoside phosphonates as inhibitors of hypoxanthine-guanine-xanthine phosphoribosyltransferase: new anti-malarial chemotherapy leads
    Symposium Series 2011, Vol. 12, pp. 171–174 [Abstract]
    Published online 2015-08-20 10:00:19
  • Melissa Williams, Ivan S. Krylov, Valeria M. Zakharova, Michaela Serpi, Larryn W. Peterson, Marcela Krečmerová, Boris A. Kashemirov and Charles E. McKenna
    Cyclic and acyclic phosphonate tyrosine ester prodrugs of acyclic nucleoside phosphonates
    Symposium Series 2011, Vol. 12, pp. 167–170 [Abstract]
    Published online 2015-08-20 10:00:12
  • Marcela Krečmerová, Tomáš Tichý, Jiří Blažek and Karel Pomeisl
    New strategies in synthesis of acyclic nucleoside phosphonate prodrugs
    Symposium Series 2011, Vol. 12, pp. 163–166 [Abstract]
    Published online 2015-08-20 10:00:06
  • Tomáš Tichý, Karel Pomeisl, Marcela Krečmerová and Charles E. McKenna
    Tyrosine-based prodrugs of acyclic nucleoside phosphonates
    Symposium Series 2014, Vol. 14, pp. 126–128 [Abstract]
    Published online 2015-07-06 22:58:53
  • Marcela Krečmerová*, Antonín Holý and Milena Masojídková
    Pyrimidine Acyclic Nucleotide Analogues with Aromatic Substituents in C-5 Position
    2007, Vol. 72, Issue 7, pp. 927–951 [Abstract]
  • Marcela Krečmerová*, Milena Masojídková and Antonín Holý
    Preparation of C-5 Substituted Cidofovir Derivatives
    2006, Vol. 71, Issue 4, pp. 579–594 [Abstract]
  • Marcela Krečmerová*, Milena Masojídková and Antonín Holý
    Synthesis of N9- and N7-[2-Hydroxy-3-(phosphonomethoxy)propyl] Derivatives of N6-Substituted Adenines, 2,6-Diaminopurines and Related Compounds
    2004, Vol. 69, Issue 10, pp. 1889–1913 [Abstract]
  • Marcela Krečmerová*, Miloš Buděšínský, Milena Masojídková and Antonín Holý
    Synthesis of Optically Active N6-Alkyl Derivatives of (R)-3-(Adenin-9-yl)-2-hydroxypropanoic Acid and Related Compounds
    2003, Vol. 68, Issue 5, pp. 931–950 [Abstract]
  • Petr Čapek, Miroslav Otmar*, Milena Masojídková, Ivan Votruba and Antonín Holý
    A Facile Synthesis of 9-Deaza Analogue of Olomoucine
    2003, Vol. 68, Issue 4, pp. 779–791 [Abstract]
  • Alois Pískala*, Naeem B. Hanna, Milena Masojídková, Miroslav Otmar, Pavel Fiedler and Karel Ubik
    Synthesis of N4-Alkyl-5-azacytidines and Their Base-Pairing with Carbamoylguanidines - A Contribution to Explanation of the Mutagenicity of 2'-Deoxy-5-azacytidine
    2003, Vol. 68, Issue 4, pp. 711–743 [Abstract]
  • Gabriel Birkuš, Ivan Votruba*, Miroslav Otmar and Antonín Holý
    Interactions of 1-[(S)-3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine (Cidofovir) Diphosphate with DNA Polymerases α, δ and ε*
    2001, Vol. 66, Issue 11, pp. 1698–1706 [Abstract]
  • Miroslav Otmar*, Lucie Poláková, Milena Masojídková and Antonín Holý
    A Facile Synthesis of Azetidin-2-ylphosphonic Acid and Its 1-Alkyl Derivatives
    2001, Vol. 66, Issue 3, pp. 507–516 [Abstract]
  • Miroslav Otmar*, Milena Masojídková, Ivan Votruba and Antonín Holý
    An Alternative Synthesis of HPMPC and HPMPA Diphosphoryl Derivatives
    2001, Vol. 66, Issue 3, pp. 500–506 [Abstract]
  • Gabriel Birkuš, Pavel Kramata, Ivan Votruba, Berta Otová, Miroslav Otmar and Antonín Holý
    Nonproteolyzed Form of DNA-Polymerase ε from T-Cell Spontaneous Lymphoma of Sprague-Dawley Inbred Rat: Isolation and Characterization
    1998, Vol. 63, Issue 5, pp. 723–731 [Abstract]
  • Pavel Kramata, Gabriel Birkuš, Miroslav Otmar, Ivan Votruba and Antonín Holý
    Structural features of acyclic nucleotide analogs conferring inhibitory effects on cellular replicative DNA polymerases
    1996, Vol. 61, Special Issue, pp. S188–S191 [Abstract]
  • Miroslav Otmar, Milena Masojídková and Antonín Holý
    Two synthetic approaches to 9-deaza analogues of 9-(2,3-dihydroxypropyl)adenine (DHPA)
    1996, Vol. 61, Special Issue, pp. S49–S51 [Abstract]
  • Marcela Krečmerová, Hubert Hřebabecký and Antonín Holý
    Synthesis of 5-Phenylcytosine Nucleoside Derivatives
    1996, Vol. 61, Issue 4, pp. 645–655 [Abstract]
  • Marcela Krečmerová, Hubert Hřebabecký and Antonín Holý
    Preparation of 5-Benzyluracil and 5-Benzylcytosine Nucleosides as Potential Inhibitors of Uridine Phosphorylase
    1996, Vol. 61, Issue 4, pp. 627–644 [Abstract]
  • Marcela Krečmerová, Hubert Hřebabecký, Milena Masojídková and Antonín Holý
    2',3'-Dideoxy- and 3'-Azido-2',3'-dideoxynucleosides of 5-Phenyl-2(1H)-pyrimidinone. Preparation of 2',3'-Dideoxypentofuranoses
    1996, Vol. 61, Issue 3, pp. 478–488 [Abstract]
  • Marcela Krečmerová, Hubert Hřebabecký, Milena Masojídková and Antonín Holý
    Synthesis of 5-Phenyl-2(1H)-pyrimidinone Nucleosides
    1996, Vol. 61, Issue 3, pp. 458–477 [Abstract]
  • Marcela Krečmerová, Antonín Holý and Milena Masojídková
    Synthesis of 3-(4-Pyridinyl)-, 3-(2-Chloro-4-pyridinyl)- and 3-(2-Amino-4-pyridinyl)propoxymethanephosphonic Acid
    1995, Vol. 60, Issue 4, pp. 670–680 [Abstract]
  • Marcela Krečmerová and Antonín Holý
    Preparation of Phosphonomethyl Ethers Derived from 2-Phenylethanol and Its Amino Derivatives
    1995, Vol. 60, Issue 4, pp. 659–669 [Abstract]
  • Miroslav Otmar, Ivan Rosenberg, Milena Masojídková and Antonín Holý
    [5-(9-Adeninyl)-5'-deoxy-L-pentofuranosyl]phosphonates: Conformationally restricted nucleotide analogs related to (S)-HPMPA
    1993, Vol. 58, Special Issue, pp. S256–S258 [Abstract]
  • Miroslav Otmar, Ivan Rosenberg, Milena Masojídková and Antonín Holý
    [5-(Adenin-9-yl)-5-deoxy-L-pentofuranosyl]phosphonates - A Novel Type of Nucleotide Analogs Related to HPMPA. II. Synthesis of L-ribo and L-xylo Configurated Derivatives by Recyclization of Diethyl (5-RS)-[1,2-O-Isopropylidene-5-O-methanesulfonyl-D-pentofuranos-5-C-yl]phosphonates under Acidic Conditions
    1993, Vol. 58, Issue 9, pp. 2180–2196 [Abstract]
  • Miroslav Otmar, Ivan Rosenberg, Milena Masojídková and Antonín Holý
    [5-(Adenin-9-yl)-5-deoxypentofuranosyl]phosphonates - A Novel Type of Nucleotide Analogs Related to HPMPA. I. Derivatives with L-arabino, D-arabino, 2-Deoxy-L-erythro and 2-Deoxy-L-threo Configuration
    1993, Vol. 58, Issue 9, pp. 2159–2179 [Abstract]
  • Marcela Krečmerová, Hubert Hřebabecký, Milena Masojídková and Antonín Holý
    Preparation of Purine 2'-Deoxy-5'-O-phosphonomethylnucleosides and 2'-Deoxy-3'-O-phosphonomethylnucleosides
    1993, Vol. 58, Issue 2, pp. 421–434 [Abstract]
  • Karel Stránský, Marta Semerdžieva, Miroslav Otmar, Želimír Procházka, Miloš Buděšínský, Karel Ubik, Jitka Kohoutová and Ludvík Streinz
    Antifungal Antibiotic from the Mushroom Agrocybe aegerita (BRIG.) SING.
    1992, Vol. 57, Issue 3, pp. 590–603 [Abstract]
  • Marcela Krečmerová, Hubert Hřebabecký and Antonín Holý
    5'-O-Phosphonylmethyl derivatives of 2'-deoxynucleosides
    1990, Vol. 55, Special Issue, pp. S121–S124 [Abstract]
  • Marcela Krečmerová, Hubert Hřebabecký and Antonín Holý
    Synthesis of 5'-O-phosphonomethyl derivatives of pyrimidine 2'-deoxynucleosides
    1990, Vol. 55, Issue 10, pp. 2521–2536 [Abstract]
  • Marcela Krečmerová, Miloslav Černý, Miloš Buděšínský and Antonín Holý
    Utilization of 1,6-anhydrohexoses for the preparation of some aliphatic adenosine analogs
    1989, Vol. 54, Issue 10, pp. 2753–2766 [Abstract]