Collect. Czech. Chem. Commun. 2011, 76, 989-995
Published online 2011-07-13 09:34:03

Microwave-assisted solvent-free synthesis of 3,4-dihydropyrimidin-2(1H)-ones catalyzed by NH4OBr

Davood Azarifara,*, Kaveh Khosravia, Khadijeh Soleimani and Zohreh Najminejada

a Department of Chemistry, University of Bu-Ali Sina, 65178 Hamedan, Iran


Catalytic potential of ammonium hypobromite in the one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones from Biginelli-type condensation reaction between an aldehyde, β-keto ester and urea has been explored. The reaction proceeds under solvent-free conventional heating as well as microwave-irradiation conditions to afford the respective products in excellent yields.

Keywords: 3,4-Dihydropyrimidin-2(1H)-one; Biginelli-type condensation; Ammonium hypobromite; Aldehydes; β-Keto ester; Urea; Solvent-free; Aromaticity; Asymmetric synthesis; C–C coupling; Heterocycles; Heterogeneous catalysis.

References: 61 live references.