Collect. Czech. Chem. Commun. 2011, 76, 829-842
Published online 2011-06-20 12:12:27

Acyclic nucleoside phosphonates: An unfinished story

Erik De Clercq

Rega Institute for Medical Research, K. U. Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium


While cidofovir, adefovir and tenofovir are the three acyclic nucleoside phosphonates (ANPs) that have been licensed for clinical use (the latter as a single-, double- and triple-drug combination), there are many more ANPs that await their application for medical or veterinary use: (S)-HPMPA, (S)-HPMPDAP, cPrPMEDAP, (R)-HPMPO-DAPy, PMEO-DAPy, 5-X-PMEO-DAPy, (R)-PMPO-DAPy, (S)-HPMP-5-azaC, and cyclic (S)-HPMP-5-azaC, and alkoxyalkyl prodrugs thereof.

Keywords: ANPs; (S)-HPMPA; Cidofovir; Adefovir; Tenofovir; Phosphonate; Veterinary; Prophylactic; Nucleotides; Nucleosides; Viruses.

References: 59 live references.